There are many variations when it comes to CBD’s bioavailability once it’s been consumed. Only a certain percentage will produce active effects which relies strongly on the manner in which you consume CBD. There are two main reasons why this happens which relate to the way CBD metabolizes in your body.
First, CBD isn’t water soluble thus CBD does not like to stay in the bloodstream. Instead, it diffuses outward and accumulates into your fatty tissues. This significantly reduces the amount of bioactive CBD that enters your systemic circulation, permitting less CBD to be carried to the active sites throughout your body.
Second, when an organic compound like CBD enters your gut, it must pass through the liver before it enters your circulation. During this process, the liver will actively reduce the amount of CBD, either through absorption or through chemical breakdown by liver enzymes. Commonly referred to the “first-pass effect”, referring to the deterioration of bioactive compounds.
There are a few ways to offset the loss of CBD though the most common and easiest ways to ensure you're utilizing CBD in the most bioavailable way is to vape it or cosume sublingually. During vaporization CBD enters the lungs and diffuses directly into the bloodstream instead of passing through the gut and liver, this also applies when dripping a CBD tincture under the tongue the only difference is the tincture enters the bloodstream without haveing to be inhaled. These methods of consumption avoid the first pass all together allowing more CBD to enter your circulation for maximum effect.